The interstitium is a thin, supportive network to the lung air sacs, which contain tiny blood vessels. Interstitial Lung Disease (ILD) is a broad category of more than 100 pulmonary conditions which result in thickening, inflammation, scarring, or edema of the interstitium lung tissues and can affect breathing and absorption of oxygen into the bloodstream.
Causes of ILD
Myositis–related autoimmune diseases such as Polymyositis, Dermatomyositis, Amyopathic Dermatomyositis, Antisynthetase Syndrome and Mixed Connective Tissue Disorder are shown to have an increased risk of ILD, especially those who test positive for the Jo-1 antibody. More than 70% of those who test positive for the Jo-1 antibody will develop ILD.
There are other numerous causes of ILD, but in some cases the diagnosis is deemed to be “idiopathic;” meaning “no-known cause.” The following have been associated with carrying a risk for ILD:
Other Causes of ILD
Remember, the causes listed in this section are potential causes and will not always result in ILD.
Medicinal Causes of ILD
Symptoms/Complications of ILD
Treatment for ILD
Corticosteroids and some immunosuppressive drugs have been used successfully to treat various forms of ILD, especially when the cause is autoimmune disease related. Rituxan (Rituximab) and IVIG have shown effectiveness in recent studies, also when autoimmune in nature.
“Simply Put” is a service of Myositis Support and Understanding, to provide overviews of Myositis-related medical and scientific information in understandable language.
MSU volunteers, who have no medical background, read and analyze often-complicated medical information and present it in more simplified terms so that readers have a starting point for further investigation and consultation with healthcare providers. The information provided is not meant to be medical advice of any type.
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