Myositis-Cancer Connection

Simply Put

Myositis and cancer have been linked since 1916, but few in-depth clinical research studies have been published. The findings of those studies, however, show an increased incidence of cancer in patients with Polymyositis and a significant increase for those with Dermatomyositis.

Whether cancer can cause Myositis is also minimally researched, but it is recognized that cancers can occur within 2 years prior to the onset of Myositis symptoms.

Higher incidence of cancer with Polymyositis and Dermatomyosits

The overall cancer rate varies between 9% and 32% for Dermatomyositis patients, most often ovarian, lung, pancreatic, colorectal, and non-Hodgkin’s lymphoma. Most of these cancers occur after the onset of Myositis symptoms, typically within the first 2 to 5 years, however colorectal and pancreatic cancer have been known to occur later than 5 years.

The most common cancers seen in patients with DM include breast, colon, lung, ovarian, melanoma, non-Hodgkin lymphoma (NHL), nasopharyngeal, and stomach.

The highest risk of developing cancer in patients with DM is within the first year of onset of myositis. Older patients and those with more severe findings on skin/muscle biopsy (cutaneous necrosis, capillary damage, and cutaneous leukocytoclastic vasculitis), prior history of cancer, and treatment resistance are at high risker of developing cancer within the DM population.

Approximately 15% of people with Polymyositis are diagnosed with cancer, most often non-Hodgkin’s lymphoma, lung, and bladder. Most of these cancers (60-70%) are discovered after the onset of Myositis. However, after one year post-diagnosis, the likelihood diminishes significantly, and by the 5th year post-diagnosis, the rate dropped to the cancer rate of the normal population.

Additional Cancer Risks

Not only do Poly- and Dermatomyositis come with a higher risk for cancer, there are other factors which increase the risk such as certain autoantibodies and the medications taken to treat Myositis.

Autoantibodies

It is important to review a patient’s recent DM-specific labs, as particular antibodies can provide insight into cancer risk. The cancer-associated myositis (CAM) antibody is linked with increased cancer risk, though patients positive for additional antibodies actually have a lower risk of developing malignancy (anti-SRP, anti-synthetase, anti-Mi-2, anti-RNP, anti-Ku, and anti-PM-Scl).

Other autoantibodies which are currently known to be associated with increased cancer rates are P155/140 and Anti T1F1 (found in DM and JDM).

Corticosteroids

A corticosteroid medication such as Prednisone/Prednisolone is most often the first line of treatment for Polymyositis and Dermatomyositis. It is highly effective in quickly treating muscle inflammation, but there is an increased risk of non-Hodgkin’s lymphoma and non-melanoma type skin cancers. The cancer risks increase with the length of time and dosage of corticosteroids. 

Immune Suppressing Medications (DMARDs)

In addition to the Myositis-cancer connection, there is a cancer connection with commonly- used immunosuppressive medications such as Methotrexate, Imuran (Azathioprine), and CellCept (Mycophenolate), all of which show an increased incidence of non-Hodgkin’s lymphoma and lung cancers.

Methotrexate is also associated with melanoma, while non-melanoma skin cancers are seen more with Imuran and CellCept.

Suggested Cancer Screenings

In addition to the Myositis-Specific Antibodies (MSA) panel (which should be conducted as part of the Myositis diagnosis and can show if cancer-related antibodies exist) regular Complete Blood Count (CBC), Comprehensive Metabolic Panel (CMP), and urinalysis (UA) should be conducted.

Patients should be up to date with all age and gender-appropriate screenings, such as mammography, pelvic exam, Pap test, and colonoscopy. In addition to these the following cancer screening tests may be suggested:

  • Pelvis and rectum (with occult blood testing)
  • Mammogram
  • CT of the chest, abdomen, and pelvis
  • Carcinoembryonic antigen (CEA)
  • Women at risk for ovarian cancer should undergo a transvaginal ultrasound.
  • All age appropriate and doctor recommended cancer screenings

NOTE: The statistics included are from research done in early 2016 and, depending on when you are reading this, may no longer be accurate. Be sure you also contact your physician should you have questions, concerns, or before deciding on a treatment due to risks shown here. This is for informational purposes only.

Simply Put

“Simply Put” is a service of Myositis Support and Understanding, to provide overviews of Myositis-related medical and scientific information in understandable language.

MSU volunteers, who have no medical background, read and analyze often-complicated medical information and present it in more simplified terms so that readers have a starting point for further investigation and consultation with healthcare providers. The information provided is not meant to be medical advice of any type.

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PIONEER, Idera clinical trial for dermatomyositis

PIONEER, Idera clinical trial for dermatomyositis

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Hi, this may be interesting to you: Myositis-Cancer Connection! The link is included below: https://understandingmyositis.org/myositis-complications/myositis-cancer/ --- Myositis Support and Understanding is a 501(c)3 nonprofit organization.